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Peptides and peptidomimetics having structural similarity to human p53 that activates p53 function
Peptides and peptidomimetics having structural similarity to human p53 that activates p53 function
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机译:与激活p53功能的人p53具有结构相似性的肽和拟肽
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摘要
The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
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