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METHOD FOR CONTINUING VECTOR EXPRESSION ACCOMPANYING WITH REPEATED ADMINISTRATION

机译:重复执行连续矢量表达的方法

摘要

PPROBLEM TO BE SOLVED: To provide a method for enabling the repeated administrations of a vector for continuing the gene expression from the vector, and a medicine enabling the execution of the method. PSOLUTION: Since when the vector is excluded by a host immune system, complement reinforces the action, then by administering a complement inhibitor on repeating the administrations of the vector by 2 times, it is possible to continue the gene expression from the vector significantly as compared with that of the case of without administering the complement inhibitor. Thereby, as the method for continuing the gene expression from the vector requiring 2 times of repeated administrations, the complement inhibitor is administered on administering the vector after 2 times of administrations. The complement inhibitor is considered as a reagent or medicine capable of continuing the expression from the repeated administration type vector. PCOPYRIGHT: (C)2007,JPO&INPIT
机译:<要解决的问题:提供一种使得能够重复施用载体以从该载体继续基因表达的方法,以及一种能够执行该方法的药物。

解决方案:由于当载体被宿主免疫系统排斥时,补体会增强作用,然后通过在重复给药2次后施用补体抑制剂来继续从载体中表达基因与不使用补体抑制剂的情况相比,具有显着的效果。因此,作为需要2次重复给药从载体中继续表达基因的方法,在2次给药后,在给予载体时给予补体抑制剂。补体抑制剂被认为是能够从重复施用型载体继续表达的试剂或药物。

版权:(C)2007,日本特许厅&INPIT

著录项

  • 公开/公告号JP2007112715A

    专利类型

  • 公开/公告日2007-05-10

    原文格式PDF

  • 申请/专利权人 DNAVEC RESEARCH INC;

    申请/专利号JP20040014702

  • 申请日2004-01-22

  • 分类号A61K45;A61K35/76;A61K48;A61P9/10;A61P35;A61P43;C12N15/09;

  • 国家 JP

  • 入库时间 2022-08-21 21:10:53

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