Parecoxib metal salts as prodrugs of the COX-2 inhibitor valdecoxib for the treatment of inflammation, pain and / or fever

摘要

Compounds having the structure MgX1X2, wherein X1 is parecoxib anion and X2 is as selected from the group consisting of parecoxib anion, chloride, bromide, sulfate, phosphate, nitrate, acetate, propionate, succinate, glycolate, stearate, lactate, malate, tartrate, citrate, ascorbate, glutamate, benzoate, salicylate, methanesulfonate, and toluenesulfonate are disclosed; also disclosed are compounds having the strucure MX1(X2)n wherein M is a metal cation selected from the group consisting of Ca2+, Zn2+, and K+; X1 is parecoxid anion; X2 is selected from the group consisting of parecoxid anion and another pharmaceutically acceptable anion; and n is 0 when M is K+ and n is 1 when M is Ca2+ or Zn2+; Compositions of the invention are useful treatment and prevention of a very wide range of disorders mediated by COX-2, including inflammation, pain and/or fever.