"PARECOXIB METAL SALTS AS PRODUCTS OF COX-2 VALDECOXIB INHIBITOR FOR TREATMENT OF INFLAMMATION, PAIN AND / OR FEVER". Compounds having the structure MgX¬ 1¬X¬ 2¬, where X¬ 1¬ is anion parecoxib and X¬ 2¬ is as selected from the group consisting of anion parecoxib, chloride, bromide, sulfate, phosphate, nitrate, acetate, propionate, succinate, glycolate, stearate, lactate, malate, tartrate, citrate, ascorbate, glutamate, benzoate, salicylate, methane sulfonate, and toluene sulfonate are shown; Also shown are compounds having the structure MX¬ 1¬ (X¬ 2¬) ~ n ~ where M is a metal cation selected from the group consisting of Ca¬ 2 + ¬, Zn¬ 2 + ¬, and K¬ + ¬; X¬ 1¬ is anion for coxib; X 2 is selected from the group consisting of an anion parecoxib and another pharmaceutically acceptable anion; and n is O when M is K¬ + ¬ and n is 1 when M is Ca¬ 2 + ¬ or Zn¬ 2 + ¬; The compositions of the invention are useful in treating and preventing a wide variety of COX-2 mediated disorders, including inflammation, pain and / or fever.
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