Method for dividing the mandelic acid by salt formation with a base cyclic amide chiral, are optionally substituted

摘要

The present invention relates to novel methods for the resolution of mandelic acid derivative from racemic mandelic acid derivative mixture by salt formation with a base cyclic amide chiral; (for example, see formulas IIa) and mandelic acid cyclic amide salt of divided metal and amine salts of certain other of mandelic acid derivatives, and relates to the use of mandelic acid derivative that has been divided as intermediates, for example, suitable for large scale production of pharmaceutical compounds; Formula (IIa), R is CHF ₂ is selected _{H, C 1~6 alkyl,} CH 2 _F, from CClF ₂ and CHCl _2; n is 0, 1 or 2 and wherein; X and is a _{C 1-6} alkyl or _{R 1} is H is _1-6 alkyl H, _C or halo.