A PROCESS FOR RESOLVING, OPTIONALLY SUBSTITUTED, MANDELIC ACIDS BY SALT FORMATION WITH A CHIRAL BASE CYCLIC AMIDE

摘要

The present invention relates to novel methods for dividing the mandelic acid derivative from the by salt formation with chiral base cyclic amides, racemic mandelic acid derivative mixture; Mandelic acid cyclic amide salt only divided (for example, the formula IIa); And certain other metal and amine salts of mandelic acid derivatives, for example, relates to the use of a mandelic acid derivative of the divided as an intermediate suitable for the large-scale manufacture of pharmaceutical compounds. ; Formula IIa ; Wherein, R is selected from CHF _2, H, C _1-6 alkyl, CH ₂ F, CHCl ₂ and CClF _2; n is 0, 1 or 2; R ₁ is H or C _1-6 alkyl; X is alkyl of H, halo or C _1-6.