Sulfide, preparation of a resin having a ligand that is bonded through a linking group consisting of sulfoxide, sulfone, or sulfonate group,

摘要

(57) A ligand capable of binding to the [Abstract] target compound, the support matrix with a ligand that is covalently bonded to the support matrix through a linking group comprising sulfide, sulfoxide, the sulfonate reactive group or a sulfone I discloses the preparation method of chromatography resin containing. In particular, in the disclosed method, the free radical conditions, is contacted with the bisulfite salt or a thiol group support matrix having an ethylenically unsaturated reactive group. In the case of the reaction with a thiol group, is oxidized to sulfoxide or sulfone sulfide as necessary.