METHODS FOR THE PREPARATION OF RESINS WITH LIGANDS ATTACHED THERETO THROUGH A LINKING GROUP COMPRISING SULFIDE, SULFOXIDE, SULFONE OR SULFONATE FUNCTIONALITY

摘要

Methods for the preparation of chromatographic resins comprising a supportmatrix having ligands capable of binding a targetcompound covalently attached thereto through a linking group comprisingsulfide, sulfoxide, sulfone or sulfonate functionality. Specifically,in the disclosed methods, a support matrix comprising ethylenicallyunsaturated functionality is contacted with a thiol group or a bisulfitesalt under free radical reaction conditions. In the case of the reaction withthe thiol group, subsequent optional oxidation of the sulfide tothe sulfone or sulfoxide functionality may occur.