Treatment of hemorrhagic shock using complement 5a receptor inhibitors

摘要

This invention relates to methods of treatment of haemorrhagic shock, and especially to treatment of this condition with cyclic peptidic and peptidomimetic compounds which have the ability to act as antagonists of the C5a receptor. In one embodiment the compounds are active against C5a receptors on polymorphonuclear leukocytes and macrophages. Particularly preferred compounds for use in the invention are disclosed.