Antiviral oligonucleotides having a conserved G4 core sequence

摘要

Modified oligonucleotides having a conserved G₄ sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus or phospholipase A₂ or to modulate the telomere length of a chromosome are provided. G₄ quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A₂ are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.