Methods for determining the sequence of a peptide motif having affinity for a substrate

摘要

Disclosed herein are methods for determining peptide motifs having binding affinity for a specified substrate. The method proceeds through the analysis of a population of peptides having some affinity for a substrate for the identification of the presence of subsequences that occur statistically more frequently than by random chance. These subsequences are then assembled into motifs having reproducible strong binding affinity for the subject substrate.