Isoxazole derivatives as peroxisome proliferator-activated receptors agonists

摘要

A compound of formula (I): (wherein R¹-R¹⁰ are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X¹ is —O—, —S—, —NR¹¹— (wherein R¹¹ is hydrogen, lower alkyl or the like), —CR¹²R¹³CO—, —(CR¹²R¹³)mO—, —O(CR¹²R¹³)m- (wherein R¹² and R¹³ are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X² is a bond, —O—, —S—, —NR¹⁴— (wherein R¹⁴ is hydrogen, lower alkyl or the like, R¹⁴ and R⁶ can be taken together with the neighboring atom to form a ring) or —CR¹⁵R¹⁶— (wherein R¹⁵ and R¹⁶ are each independently hydrogen or lower alkyl, R¹⁵ and R⁶ or R¹⁰ can be taken together with the neighboring carbon atom to form a ring, R¹⁶ and R⁹ can be joined together to form a bond), X³ is COOR¹⁷, C(═NR¹⁷)NR¹⁸OR¹⁹ or the like), a pharmaceutically acceptable salt or a solvate thereof.