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Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa)
Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa)
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机译:通过激活钙激活钾通道(K Ca Sub>)诱导恶性细胞选择性细胞死亡的方法
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摘要
Disclosed are a method of inducing apoptosis of a malignant cell, which employs a calcium-activated potassium channel (KCa) activator and is useful for treating a malignant tumor in a human subject. Also disclosed are methods of selectively inhibiting the proliferation of malignant cells compared to non-malignant cells in a mixed population of malignant and non-malignant cells and of inhibiting the growth of a malignant tumor, such as a glial tumor, in a mammalian subject. A kit for inducing apoptosis of malignant cells is also disclosed.
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机译:公开了一种诱导恶性细胞凋亡的方法,该方法采用钙激活的钾通道(K Ca Sub>)激活剂,可用于治疗人类受试者的恶性肿瘤。还公开了在哺乳动物受试者中在恶性和非恶性细胞的混合群体中与非恶性细胞相比选择性地抑制恶性细胞的增殖以及抑制恶性肿瘤例如神经胶质瘤的生长的方法。还公开了用于诱导恶性细胞凋亡的试剂盒。
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