Convenient method for the preparation of new precursor of no-carrier-added O-(2-18Ffluoroethyl)-L-Tyrosine)

摘要

This is a new precursor and new method for the synthesis of no-carrier-added O-(2-[¹⁸F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging, the preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R¹ is a protective group for the carboxyl functional group, R² is a protective group for the amino group, and R³ acts as a leaving group. R¹ represents an arylalkyl group, R² represents a carboxyl group, and R³ represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine, the invention includes a method for the syntheses of new precursors with the chemical structures as in Formula 1.