A convenient method for the preparation of no-carrier-added O-(2-18Ffluoroethyl)-L-Tyrosine)

摘要

This is a novel method for production of no-carrier-added O-(2-[¹⁸F]fluoroethyl)-L-Tyrosine which has been proved a suitable PET (position emission tomography) probe for tumor diagnosis imaging.;The preparation of the title compound starts from precursors with the chemical structures as in Formula 1, wherein R1 is a protective group for the carboxyl functional group, R2 is a protective group for the amino group, and R3 acts as a leaving group. R1 represents an arylalkyl group, R2 represents a carboxyl group, and R3 represents a p-tosyloxy, methane sulfonyloxy or trifluoromethane sulfonyloxy or bromine. The final purification of the product is using a separation column, which is very convenient for automated synthesis. The invention uses the precursor with the chemical structures as in Formula 1.Formula 1 : Synthesis precursors for O-(2-C18F]fluoroethyl)-L-Tyrosine.