Benzimidazole derivatives; Synthesis thereof; Pharmaceutical compositions containing them and their use in the preparation of drugs for the treatment of diseases mediated by CB1 receptor ligands.

摘要

Pharmaceutical compositions comprising the compounds of the present. These are useful in therapy, particularly in the management of Pain, and in the preparation of drugs for the treatment of cancer, multiple sclerosis, Parkinson's disease and Alzheimer's disease.Claim 1: a compound of formula (1), its pharmaceutically acceptable Salt, Diastereomers, enantiomers or mixtures thereof in which G is selected between - - and - - or CF2; r1 is selected from alkyl and cycloalkyl C1 - C3 - 6 - 6; R2 is selected from H and methyl; and R3, R4 and R5 are Select Mr ionan independently between F and methyl.Claim 1: a method for preparing a compound of formula (1), which comprises reacting a compound of formula (2) with a compound of formula (3), where G is selected from - - - - - - CF2 and CHF; r1 is selected from alkyl and cycloalkyl C1 - 6 C3 - 6; R2 is selected from H Methyl; and R3, R4 and R5 are selected independently between F and methyl.