Aminotiofeno compounds (espirociclilamido)

摘要

Aminoethylamine compounds (Spirulina) are effective tools for the treatment of tumors and cancers, such as mastitis / breast cancer, gastrointestinal estrogen tumor (GIST),Bacterial tumor, small cell lung cancer (SCLC),Acellular lymphoma NK / T cell, testicular cancer (half cell cancer)Thyroid cancer, malignant melanoma, ovarian cancer, adenosine chemical cancer, acute poliomyelitis (AML),Pediatric T-cell neurocytoma with breast cancer and acute lymphocytic leukemia Mastitis, leukaemia, hemangioma, large cell lymphoma, uterine cancer and prostate cancer. Item 1: the compound represented by formula (1), or the salt or positive oxidant acceptable from the formula, in the formula: and it is isomerized or cyclochloro 3-10 tar, any of which can be replaced by an independent R5 substitute of 1-5; X is isomerized or acylated, Any of them can choose to use 1-5 independent R21 substitutes, namely arilo, heteromorphic, cyclochloro 3-10oquilo, isocyclopropylene,cicloC3-10alquenilo o heterocicloalquenilo cada uno de los cuales est opcionalmente sustituido con 1-5 sustituyentes R3 independientes R1 es C0-6alquilo halogeno o haloalquilo R2 R21 y R3 son cada uno independientemente cicloC3-10alquilo oxo halogeno haloalquilo C0-6alquilo cianoC0-6alquilo nitroC0- -N (C0-6alquil) -N (C0-6alquil) (C0-6alquil)N (C0-6alquil) -N (C0-6alquil) (acil)acylC0-6alkyl, substituted acyl, guanidinoC0-6alkyl, hydroxyiminoC0-6alkyl, acylaminoC0-6alkyl, substituted acylamino, acyloxyC0-6alkyl, substituted acyloxy, arC0-6alkyl, arC0-6alkyl substituted, heteroalkylC6- heteroalkylC6-6alkylC6-6alkylC6-6alkyl-heteroalkylC6-alkylC6 , cianoaminoC0-6alquilo, C0-6alquilhidrazino, heterocyclic, arC0-6alquilhidrazino, alquilsulfonilC0- 6alquilo, arC0-6alquilsulfonilC0-6alquilo, alquilsulfinilC0-6alquilo, alquilsulfonamidoC0-6alquilo, arC0-6alquilsulfonamidoC0-6alquilo, aminoC0-6alquilsulfonilo, C0-6alquilaminosulfonilo, acilC1-6alquilsulfonilo , heterocyclylsulfonyl, aminoC0-6alkylsulfinyl, acylC1-6alkylsulfinyl, silyl, siloxy,alkenoxy, alkynoxy, C2-6alkenyl, acilC2-6alquenilo, C2-6, acilC2-6alquinilo, hidroxiC2-6alquinilo, aminoC2-6alquinilo, C1-6alcoxiC0-6alquilo, C1-6alquiltioC0-6alquilo, hidroxiC1- 6alcoxiC0-6alquilo, hidroxiC1-6alquiltioC0- 6alquilo, acilC1-6alcoxiC06alquilo, acilC1-6alquiltioC0-6alquilo, C0-6alquilaminoC1-6alcoxiC0-6alquilo, C0-6alquilaminoC1-6alquiltioC0-6alquilo, acilaminoC1-6alcoxiC0-6alquilo, acilaminoC1-6alquiltioC0- 6alquilo, arC0-6alquilaminoC0-6alquilo, arC0-6alquiltioC0- 6alkyl, arC0-6alkoxyC0-6alkyl, arC0-6alkylamino, arC0-6alkylaminoC0-6alkyl, arC0-6alkylthio, arC0-6alkoxy substituted, arC0-6alkylthio substituted, or arC0-6alkoxy substituted;y siempre que el compuesto no sea cis-N- (4-metil-5-oxo-1 4-diazaespiro 5 5 undec-9-il) -3- (quinolin-4-ilmetil) amino tiofeno-2-carboxamida cis- 2-1,2-chlorodi-hydrogen-fluorine] - fluorine [1] - fluorine] - spirit] - 1 - [1 - [1]]]]]]] - 1 - [1]] - key.