Aminotiofeno compound and its use for the preparation of a Pharmaceutical composition

摘要

A compound of Aminotiofeno has the following formula (1): in which R1 represents nr4r5; R2 represents CONH2 or so2nh2; R3 represents Three substituents selected from the group formed by c1-4 alkyl, halogen, NF3, or alkyl alkyl -, S -, CN; Cho, SO2 and NO2 - alkyl; R4 represents H OR C1-2 alkyl; R5 represents C (=) nhr6, cor7 or R6 represents; or,S or N; R6 represents H or alkyl c1-2 alkyl; R7 represents C1 - 2; l is a Linking Group D - e - D where D represents a link or a c1-4 alkyl; e represents - C = C (g) - (i), with, nhco, COO, n o, S, or S, and G and R independently represent H or alkyl c1-2; or a Pharmaceutical Salt ACE Ptable themUnder the condition of the compound of formula (1) is not [2 - (Aminocarbonyl) amino] - 5 - [(4-chlorophenyl) methyl] - 3 - tiofenocarboxamida oxi. Use of said Compound for preparing a Pharmaceutical composition to be used in the treatment of diseases with inhibitors of the phosphorylation of IKB Protein by Enzyme aminotiofenos IKK - B type.In doing so, these inhibitors block the type of aminotiofenos Pathological Activation of transcription factor NF Kb in Diseases involving excessive Activation of NF Kb.These compounds are of use in the treatment of inflammatory disorders and separation of tissues, particularly rheumatoid arthritis, Asthma, chronic obstructive pulmonary disease, Osteoarthritis, autoimmune diseases, rejection of Tissue and Organs, Alzheimer's disease, resteno SIS, Diabetes and glomerulonephritis.