Compounds of N - sulfonilaminofeniletil - 2 - substituted fenoxiacetamida, Pharmaceutical compositions containing same and use in preparation of drugs for the treatment of diseases mediated by VR1 receptor

摘要

A formula compound (1),wherein R1 represents C1-6 alkyl; R 2 represents a hydrogen atom, a halogen atom, a hydroxy group, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxy, C 1-6 alkoxy or C 1-6 alkyl or halo C 1-6 alkyl; R 3 represents a halogen atom, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxy, C 1-6 alkoxy, C 1-6 alkoxy, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 alkylthio, C 1-6 alkyl sulfinyl, C 1-6 alkyl sulfonyl, C 1-6 alkyl NH- or (C 1-6 alkyl) 2N-;R4 represents a halogenated atom, C1-6 tar, C1-6 halogenated tar, Alcoy C1-6, hydroxi-alcoxc1-6, alcoxc1-6-quiloc1-6, alcoxc1-6-alcoxc1-6, tar 1-6nh -,o (alquil C1-6) 2N-R 5 represents a halogen atom, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxy, C 1-6 alkoxy, C 1-6 alkoxy, C 1-6 alkoxy, C 1-6 haloalkyl, C 1-6 alkylthio, C1-6-sulfinyl alkyl, C1-6-sulfonyl alkyl, C1-6NH- alkyl,(C1-6 tar) 2n -,H2N-C1-6 alkoxy, C1-6 alkyl-NH-C1-6 alkoxy, (C1-6 alkyl) 2N-C1-6 alkoxy, H2N-C1-6 alkoxyC1-6 alkyl, C1-6 alkyl-C1-6 alkoxy-C1-alkyl 6 or (C1-6 alkyl) 2N-C1-6 alkoxy-C1-6 alkyl; and * indicates a chiral center; or a pharmaceutically acceptable salt thereof or a solvate thereof. These compounds are useful for the treatment of disease states caused by overactivation of the VR1 receptor such as pain or the like in mammals. This present also causes a pharmaceutical composition comprising the above compound.