System and Method for Preventing Bacterial and fungal infections that include urinary tract infections (UTIs) using N - Halogenated amino acids

摘要

It reveals a system that prevents the development of infection and the establishment of a Biofilm on Medical Devices in general and, in particular, urinary tract infections (UTIs), which include a catheter associated urinary tract infections (ituac).The system includes a Medical Device (such as a catheter) and an antimicrobial composition containing an antimicrobial Compound. A Medical Device manages the composition of both the Inner and Outer portions of the device, as well as the inside of the bladder and the Urethra itself.The reduction or elimination of the infection can be achieved by Irrigation of the medical device, through the bathroom of the bladder, or by Irrigation of bladder with composition.Claim 1: a system of antimicrobial Treatment comprises (a) a Medical Device implantation or for insertion in a patient at risk of, or affected by, a microbial infection; and (b) an aqueous antimicrobial composition comprising a composition comprising (1) A C And effective for antimicrobial use at least one amino acid n - Halogenated,A derivative thereof or a Derivative of the amino acid n - a source of halogen or Halogenated amino acid n - or mixtures thereof; (2) and optionally at least one type of Halide Salt selected from the group consisting of Sodium Chloride, Sodium bromide, potassium chloride, POTASSIUM BROMIDE, CL Oruro MagnesiumMAGNESIUM BROMIDE and mixtures thereof; Halide Salt concentration ranging from 0.05 to about 20 g / l, preferably from about 2 to 20 g / l, more preference of about 4 to about 20 g / l aqueous composition; (3) a pH of about 2 to about Share 8; and (4) optionally, an effective amount of HOBr or HOCl for antimicrobial use.Or a source or composition capable of releasing HOBr or HOCl (5); and optionally a constituent selected from the group consisting of pH adjusting agents, chelating agents, calcium and magnesium, acids and / Or Biologically acceptable salts thereof which are compatible with the system. Attachment antimicrobialAnd mixtures thereof to keep the PH in the range of between approximately 2 and 8.