aptamers for the human il-12 cytokine family and their use as an autoimmune disease therapy

摘要

FITNESS FOR THE IL-12 HUMANA CYTOKINE FAMILY AND ITS USES AS AUTO-IMMUNE DISEASE THERAPY. The present invention provides materials and methods for treating immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in treating autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding human and / or IL-12 and human cytokines and thus modulating their biological activities and are useful as therapeutic agents in immune therapy, immune and cancer.