MICRO-EMULSION PREPARATION WITH HIGH CONCENTRATION OF PROPHOPOL FOR ANESTHESIC APPLICATIONS

摘要

The invention provides a method and composition for increasing the dissolution and bioavailability of propofol (2,6-diisopropylphenol) for use as an intravenously administered anesthetic in mammals. According to this method, a base composition of a self-emulsifying emulsion is prepared, which is used to make a water-based microemulsion preparation. In a preferred two-component (2) base composition, it consists of a surfactant containing polyethylene glycol and liquid propofol. A microemulsion is prepared by mixing this base composition with a carrier fluid, which leads to the formation of a microemulsion containing propofol concentrations up to about 4 wt.% Propofol to the volume of the microemulsion. In a four-component (4) base composition, it consists of a surfactant containing polyethylene glycol; liquid propofol; water-immiscible solvent and ethanol. A microemulsion is prepared by mixing this base composition with a carrier fluid, which leads to the formation of a microemulsion containing propofol concentrations up to about 10 wt.% Propofol to the volume of the microemulsion.