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RESOLUTION OF RACEMIC MIXTURE OF SERTRALINE AND IMPROVED PROCESS FOR THE PREPARATION OF ITS HYDROCHLORIDE SALT.
RESOLUTION OF RACEMIC MIXTURE OF SERTRALINE AND IMPROVED PROCESS FOR THE PREPARATION OF ITS HYDROCHLORIDE SALT.
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机译:舍曲林的消旋混合物的解析及制备其盐酸盐的改进方法。
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摘要
The invention disclosed in this application relates to an improved process for the preparation of cis- (1 S, 4S)-N-methyl-4- (3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1- naphthaleneamine hydrochloride, commonly known as sertraline, from its racemic mixture by employing (R)-naproxen and its conversion to sertraline hydrochloride by novel methods which are environmentally friendly.
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