DISUBSTITUTED PYRAZOLOBENZODIAZEPINES USEFUL AS INHIBITORS FOR CDK2 AND ANGIOGESIS, AND FOR THE TREATMENT OF BREAST, COLON, LUNG AND PROSTATE CANCER.

摘要

The present invention provides compounds of the formula (I) wherein R1,R2, R3 and R4 are described herein. The inventionalso provides syntheses for preparation of such compounds and pharmaceuticalcompositions containing them. The invention further provides methods for inhibitingkinases, in particular CDK2, for inhibiting angiogenesis, and for treatingcancers, in particular breast, colon, prostate, and lung cancer.