Pyrethroid and ethynopyridine derivatives as the antitube of metabotropic glutamate receptor (mGluRs)

摘要

It refers to a compound of formula I, wherein R1 represents halide, cyanide, nitric acid, CHO, alcox, etc.; R2 represents C (o) R3, wherein R3 represents tar,a. X is ch, N; X2 is a simple link, an alcandil group, etc;Y1 is O, Y2 is h, M is 0.1, n is 1, 2, P is 0 to 5. They are the most popular compounds [4 - (3-chloro-phenyl) - 4-h-phenyl-pyridine-1-nil] - methane, [4 - (3-chloro-phenyl) - 4-hydroxy-pyridine-4-nil] - (1-methyl-pyridine-4-nil) - methane, [4 - (3-chloro-phenyl) - 4-hydroxy-pyridine-pyridine He also mentioned a drug synthesis and a preparation procedure. These compounds are antagonists of metabotropic glutamate (mGluRs), which can be used to treat epilepsy; functional disposia, anxiety, depression