Benzoazolylpiperazine derivatives having metabotropic glutamate receptor 1 and receptor 5 (mGluR1- and mGluR5-) antagonistic activity

摘要

Benzoazolylpiperazine derivatives and pharmaceutically acceptable salt thereof having metabotropic glutamate receptor 1 (mGluR1) and metabotropic glutamate receptor 5 (mGluR5-) antagonistic activity are disclosed, wherein these benzoazolylpiperazine compounds can be represented by formula (Ia), (IIb), (IIIa) etc., wherein Ar1, A, R3, x, and m are as defined in the specification. These benzoazolylpiperazine compounds are useful for inhibiting VR1 function in a cell and are suitable for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, retricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal.