DIASTEREOMER SALTS OF (±)-ALPHA-(DIFLUOROMETHYL)ORNITHINE-MONOHYDROCHLORIDE MONOHYDRATE AND METHOD OF SEPARATION OF (+)- ALPHA-(DIFLUOROMETHYL)ORNITHINE

摘要

(±)-alpha-(Difluoromethyl)-ornithine is separate into its isomers using (-)-O,O'-di-p-toluoyl-L-tartaric acid. (-)-alpha-(Difluoromethyl)-ornithine monohydrochloride monohydrate and in particular the (-)-isomer are inhibitors of ornithine decarboxylase and thereby have numerous pharmacological actions.