Variant of bile salt-stimulated lipase, DNA molecules encoding them, and transgenic non-human mammals

摘要

The present invention relates to polypeptides which are variants of Bile Salt-Stimulated Lipase (BSSL; EC 3.1.1.1), DNA molecules encoding the said polypeptides, processes for producing the said BSSL variants and producing transgenic non-human mammals capable of expressing the BSSL variants. Furthermore the invention relates to such transgenic non-human mammals as well as to infant formulas comprising milk from such transgenic animals, pharmaceutical compositions comprising the said polypeptides, and the use of the said polypeptides and DNA molecules for the manufacture of medicaments.