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biodegradable polyurethanes non-toxic for controlled drug release and tissue engineering.

机译:可生物降解的聚氨酯,对控制药物释放和组织工程无毒。

摘要

biodegradable polyurethanes nontoxic to release controlled drug and for tissue engineering.; The object of the invention is a biodegradable polyurethane hydrophilic character setting / hidrofóbi- co whose degradation products are non-toxic, and containing in the main chain at least one amino acid residue, which makes it recognizable by biological agents. The polymers are synthesized from a long chain monomer, as is a polyol consisting of a copolymer with units or segments of different hydrophilic / hydrophobic character, a di- or polyisocyanate and a chain extender, so that the degradation products of these three basic components do not result in toxic products and the structure of the main chain includes at least one amino acid residue.; The main applications are based on use as a material for the production of products intended for pharmaceutical and biotechnology industry, specifically its main application is for transport and controlled drug for tissue engineering and release.
机译:可生物降解的聚氨酯,对释放控制药物和组织工程无毒。发明内容本发明的目的是一种生物可降解的聚氨酯亲水特性设定剂/hidrofóbico,其降解产物是无毒的,并且在主链中包含至少一个氨基酸残基,这使得它可以被生物试剂识别。聚合物由长链单体合成,多元醇也是由具有不同亲水/疏水特性的单元或链段的共聚物,二异氰酸酯或多异氰酸酯和扩链剂组成的多元醇,因此这三种基本组分的降解产物不会产生有毒产物,并且主链的结构包括至少一个氨基酸残基。主要应用是基于用作生产用于制药和生物技术行业的产品的材料,特别是其主要应用是用于组织工程和释放的运输和受控药物。

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