Acid 1-1,4,7,10-tetraazacyclododecane-pirazoliletil-4,7, 10-triacetic. Application of the complex gadolinium (III) in clinical diagnosis.; macrocyclic compounds of General Formula A paramagnetic lanthanide complexes which are used as contrast agents for Magnetic Resonance Imaging.; Compounds of General Formula A wherein R7 and / or R2 are hydrogen, methyl groups, nitro groups and amino groups. A process for the preparation of these compounds from the corresponding bromoetilpirazoles, which involves the following steps:; 1) monoalkylation of cyclen; 2) alkylation of the remaining amino groups with methyl bromoacetate in basic medium and finally, 3) the basic hydrolysis of methyl esters to obtain the corresponding trisodium salt.; The complexes of Gd (III) and other lanthanides obtained from compounds of general formula A, the process for obtaining complexes and their experimental use and clinical in the manufacture of contrast agents for clinical imaging of Magnetic resonance.
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