ORAL PHARMACEUTICAL COMPOSITIONS OF CONTROLLED LIBERATION OF MESALAZINE.

摘要

An oral controlled-release pharmaceutical composition containing as active ingredient 5- aminosalicylic acid, comprising: a) an internal lipophilic matrix consisting of substances with a melting point below 90 ° C in which the active ingredient is at least partially dispersed ; b) an external hydrophilic matrix in which the lipophilic matrix and the active ingredient are dispersed; in which the composition releases up to 90% of the active agent in 8 hours immersion in simulated enteric juice.