DERIVATIVES OF STAUROSPINE AS INHIBITORS OF THE ACTIVITY OF THYROSINE QUINASA RECEPTORA FLT3.

摘要

The use of a staurosporine derivative selected from the compounds of ** formula ** wherein R1 and R2 are, independently of each other, alkyl unsubstituted or substituted by halogen, C6-C14 aryl, hydroxy, C1-C7 alkoxy, phenyl (C1-C7) alkoxy or phenyloxy, C1-C7 alkanoyloxy or benzoyloxy, amino, (C1-C7) -amino, (C1-C7) alkanoyl-amino, phenyl-(C1-C7) -amino, N , N-di-(C1-C7) -amino, N, N-di- (phenyl-C1-C7) alkyl-amino, cyano, mercapto, (C1-C7) alkyl-thio, carboxy, alkoxy ( C1-C7) -carbonyl, carbamoyl, N-mono- or N-alkyl (C1-C7) -carbamoyl or N, N-di-alkyl (C1-C7) -carbamoyl, sulfo, alkane (C1-C7) -sulfonyl or (C1-C7) alkoxy-sulfonyl, aminosulfonyl or N-mono- or N-(C1-C7) -aminosulfonyl or N, N-di-(C1-C7) -aminosulfonyl; hydrogen; halogen; hydroxyl; C1-C7 alkoxy; C8-C14 aryloxy; aryl (C6-C14) -alkoxy (C1-C7); C1-C7 alkanoyloxy; aryl (C6-C14) -carbonyloxy; Not me; amino monosubstituted or disubstituted by C1-C7 alkyl, C6-C14 aryl, (C6-C14) aryl (C1-C7) alkyl, C1-C7 alkanoyl or (C8-C12) -carbonyl; cyano; nitro; mercapto; (C1-C7) alkylthio; aryl (C8-C14) -thio; aryl (C8-C14) -alkyl (C1-C7) -thio; (C1-C7) alkanoyl-thio; aryl (C8-C14) -alkanoyl (C1-C7) -thio; carboxy; (C1-C7) alkoxycarbonyl; aryl (C8-C14) -alkoxy (C1-C7) -carbonyl, aryloxy (C6-C14) -carbonyl; carbamoyl; N-monosubstituted or N, N-disubstituted carbamoyl by C1-C7 alkyl, C8-C14 aryl or (C6-C14) aryl (C1-C7) alkyl; sulfo; aryl (C6-C14) -sulfonyl; aryl (C8-C14) -alkane (C1-C7) -sulfonyl; (C1-C7) alkane-sulfonyl; aminosulfonyl or N-monosubstituted or N, N-disubstituted by C1-C7 alkyl, C6-C14 aryl or (C6-C14) aryl (C1-C7) alkyl; n and m are, independently of each other, a number from and including 0 to and including 4; n '' and m '' are, independently of each other, a number from and including 1 to and including 4; R3, R4, R6 and R10 are, independently of each other, hydrogen, a C1-C7 alkyl, C1-C7 alkenyl, C1-C7 alkynyl or C1-C7 straight or branched chain alkynyl, saturated or unsaturated, substituted by acyclic substituents, C1-C29 carbocycle or (C1-C29) carbocycle-(C1-C7) alkyl, (C1-C29) carbocycle-C1-C7 alkenyl, a heterocycle with up to 20 carbon atoms and up to 9 heteroatoms, or heterocycle-C1-C7 alkyl with up to 20 carbon atoms and up to 9 heteroatoms.