PIRIDINE DERIVATIVES WITH INHIBITING ACTIVITY OF QUINASA IKB (IKK-BETA).

摘要

A pyridine derivative of formula (I) in which -R1 represents or in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkyl-sulfonylamino, C1 alkoxy -6-carbonyl, C1-6-alkyl, di (C1-6-alkyl) amino, C1-6-alkanoyl-amino, phenyl-C1-6-amino alkyl, phenylsulfonylamino or -O- (CH2) n-R111, representing n a integer selected from 0 to 6, and R111 is C2-6 alkenyl, benzoyl, diphenylmethyl, di (C1-6 alkyl) amino, C1-6 alkanoyl, C1-6 alkoxycarbonyl, or a saturated or unsaturated ring of 3 to 10 members having 0 to 3 heteroatoms selected from the group consisting of S, O and N as heteroatoms and is optionally substituted with C1-6 alkyl, mono or dihalogen, C1-6 alkyl substituted with halogen, nitro, cyano, C1- alkoxy 6-carbonyl, phenyl, hydroxy, amino, C 1-6 alkyl, di (C 1-6 alkyl) amino, C 1-6 alkanoyl, C 1-6 alkoxy or carbamoyl; R2 represents hydrogen or halogen; R3 represents hydrogen or 1,2,3,6-tetrahydropyridine, -CR31R32R33, wherein R31 is hydrogen or C1-6 alkyl, R32 is hydrogen, a-aminobenzyl, C1-6 alkyl optionally substituted with one or two substituents selected from the group consisting of hydroxy, amino, amino substituted phenyl, phenyl, halogen substituted phenyl and C1-6 alkoxy substituted phenyl, or a 5 to 8 membered saturated ring having 0 to 3 atoms selected from the group consisting of S, O and N as heteroatoms and optionally substituted with C1-6 alkyl, and R33 is hydrogen, amino, C1-6 alkoxycarbonylamino, C2-6 alkenyl-oxycarbonylamino, piperidine-C1-6 alkylcarbonylamino, piperidinyl-C1-6 alkyl -carbonylamino, or R32 and R33 can form, together with the adjacent carbon atom, a saturated ring of 5 to 8 members having 0 to 3 heteroatoms selected from the group consisting of N, O and S as heteroatoms, said ring being optionally substituted with C1-6 phenylalkyl, C1 phenylalkyl -6 substituted with C1-6 alkoxy, C1-6 alkyl, amino, cyano, hydroxy, carbamoyl, carboxy, C1-6-amino alkyl, C1-6 alkoxycarbonyl, di (C1-6 alkyl) amino, benzylamino, alkyl C1-6-sulfonyl, piperidine-C1-6 alkylcarbonyl or optionally condensed with benzene; or -NR34R35, wherein R34 is hydrogen or C1-6 alkyl; or one of its salts.