BENZOTIEPINIC INHIBITORS OF THE TRANSPORT OF BILIAR ACIDS PRESENT IN THE ILEON.

摘要

A compound of ** formula **, in which: One of R1 and R2 is selected from hydrogen or C1-6 alkyl and the other is selected from C1-6 alkyl; RX and RY are independently selected from hydrogen, hydroxy, amino, mercapto, C1-6 alkyl, C1-6 alkoxy, N- (C1-6 alkyl) amino, N, N- (C1-6 alkyl) 2amino, C1- alkyl 6-S (O) a in which a is 0 to 2; Rz is selected from halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C2-6 alkoxy, C1-6 alkanoyl, C1- alkanoyl 6-oxy, N- (C1-6 alkyl) amino, N, N- (C1-6 alkyl) 2amino, C1-6 alkanoyl, N- (C1-6 alkyl) -carbamoyl, N, N- (alkyl C1-6) 2carbamoyl, C1-6-S (O) alkyl in which a is 0 to 2, C1-6 alkoxycarbonyl, N- (C1-6 alkyl) sulfamoyl and N, N- (C1- alkyl 6) 2sulfamoyl; v is 0-5, R3 and R6 and the other of R4 and R5 are independently selected from hydrogen, halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, sulfamoyl, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C1-4 alkanoyl, C1-4 alkanoyl-oxy, N- (C1-4 alkyl) amino, N, N- (C1-4 alkyl) 2amino, C1-4 alkanoyl-amino , N- (C1-4 alkyl) -carbamoyl, N, N- (C1-4 alkyl) 2carbamoyl, C1-4-S (O) alkyl in which a is 0 to 2, C1-4 alkoxycarbonyl, N- (C1-4 alkyl) sulfamoyl and N, N- (C1-4 alkyl) 2sulfamoyl; wherein R3 and R6 and the other of R4 and R5 may optionally be substituted on the carbon with one or more R16; X is -O-, -N (Ra) -, -S (O) b- or -CH (Ra) -.