PHARMACEUTICAL COMPOSITIONS OF ANTICOLINERGIC AND INHIBITORS OF QUINASE P38 IN THE TREATMENT OF RESPIRATORY DISEASES.

摘要

Pharmaceutical compositions characterized in that they contain one or more anticholinergics of the formula A (See formula) in which X- means an anion (counterion), preferably an anion chosen from the group consisting of chloride, bromide, iodide, sulfate, phosphate, methanesulfonate , nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate and p-toluenesulfonate; combined with one or more p38 kinase B inhibitors, optionally in the form of enantiomers, mixtures of enantiomers or in the form of racemates thereof, optionally in the form of solvates or hydrates and optionally together with a pharmaceutically acceptable excipient; characterized in that the inhibitors B of the kinase p38 are chosen from the group of the compounds of the formulas 5, 5a, 6 and 7, in which in the compounds of the formula 5 (See formula) Ar1 is chosen from the group consisting of : pyrrole, pyrrolidine, pyrazole, imidazole, oxazole, thiazole, furan and thiophene; said Ar1 may be substituted by one or more R1, R2 or R3; Ar2 is: phenyl, naphthyl, quinoline, isoquinoline, tetrahydronaphthyl, tetrahydroquinoline, tetrahydroisoquinoline, benzimidazole, benzofuran, indanyl, indenyl or indole, each of which is optionally substituted one to three times by R2 groups; X is: a) a C5-8 cycloalkyl or cycloalkenyl optionally substituted by 0-2 branched or unbranched C 1-4 alkyl groups, C 1-4 alkoxy or C 1-4 alkyl amino; b) phenyl, furan, thiophene, pyrrole, imidazolyl, pyridine, pyrimidine, pyridinone, dihydropyridinone, maleimide, dihydromaleimide, piperidine, piperazine or pyrazine, which independently of each other may optionally be substituted by 0-3 C1-C alkyl groups 4 branched or unbranched, C1-4 alkoxy, hydroxy, nitrile, mono- or di- (C1-3 alkyl) amino, C1-6-S (O) alkyl or halogen.