USE OF DELTA OPIOID RECEPTOR AGONISTS IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR APPLICATIONS IN THE TREATMENT OF TUMOURS

摘要

This invention is based on the blocking effect of the DPDPE agonist on the intramolecular signalling cascade initiated by the CXCL12-CXCR4 pair, which induces tumour progression and the formation of metastases. Thus, the invention describes the fact that the treatment with DPDPE in vivo reduces metastases in animal models by means of a mechanism that does not involve an immune response.