INDUCIBLE CELLULAR IMMUNITY THROUGH ACTIVATION OF TH1 AND SUPPRESSION OF TH2 RESPONSES BY MACROPHAGES

摘要

The present invention relates to the use of macrophages in the function ofantigen presenting cells (APC) to redirect the balanceof the CD4+ T helper 1(Th1)/CD4+ T helper 2(Th2) cell subsets during an immuneresponse. More particularly, the present inventionis directed to pharmaceutical formulations comprising macrophages or a cellpopulation containing macrophages, optionally together witha suitable excipient, and methods for suppressing the Th2 dependent humoralimmune response and/or to stimulate the Th1 dependent,cellular immune response.