CELL-SPECIFIC RETROVIRAL VECTORS WITH ANTIBODY DOMAINS AND METHOD FOR THE PRODUCTION THEREOF FOR SELECTIVE GENE TRANSFER

摘要

The invention relates to cell-specific retroviral vectors with antibodyrecognition domains(scFv), which are suitable for cell-specific transduction of a selected mammalcell type (celltargeting), to methods for the production of the cell-specific retroviralvectors and to the usethereof in gene transfers into selected cells. The invention further relatesto retroviralpackaging cells to obtain cell-specific retroviral vectors according to thepresent invention.