METHOD FOR INHIBITING CALCIFICATION OF ALDEHYDE-FIXED BIOPROSTHETIC MATERIALS

摘要

A method for preparing collagenous biological tissues for use as implantablebioprosthetic material, and articles prepared thereby.The method generally comprises the steps of a) contacting the tissue with analdehyde fixative to effect cross-linking of the connectivetissue protein(s) and subsequently b) contacting the tissue with apolyglycidyl ether. The treatment of the cross-linked tissue with thepolyglycidyl ether serves to mitigate the tissue's propensity to undergocalcification following implantation in the body.