METHODS AND SYSTEMS FOR EVALUATING HEALTH RISK FACTORS BY MEASUREMENT OF DNA DAMAGE AND DNA REPAIR

摘要

Disclosed are methods for measuring the effects of environmental,physiological, or lifestyle variables on DNA damage and DNA repair activity aswell as the use of measurements of DNA damage and DNA repair activity topredict increased risk for disease. Embodiments of the methods involve the useof a combination of assays to measure DNA damage and DNA repair activity in anindividual and comparing these measurements to suitable controls using theselected assays for normal healthy individuals of varying ages. In otherembodiments, the methods may comprise a comparison of DNA damage levels to DNArepair levels to obtain an apparent net measurement of DNA damage accumulation.