Use of EGF-R protein tyrosine kinase inhibitors for preventing photoaging in human skin

摘要

Photoaging of human skin, such as evidenced by the increased presence of matrix metalloproteinases after exposure to UV radiation, is prevented by pre-treating the skin with an inhibitor of epideremal growth factor receptor (EGF-R) prior to exposure. Such inhibitors are preferably natural, an example of which is geniestein. Compositions used for such purposes preferably include an EGF-R inhibitor as well as another MMP inhibitor, such as a retinoid.