MICROSPHERES CONTAINING GOSERELIN OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

摘要

The present invention provides a sustained release microsphere composition comprising (i) microspheres comprising (A) a biodegradable polymer which is a homopolymer of lactic acid or a copolymer of lactic acid and glycolic acid having a monomer ratio in the range of about 1:1 to about 3:1, and (B) a therapeutically effective amount of goserelin or a pharmaceutically acceptable salt thereof, and (ii) pharmaceutically acceptable excipients, which when injected intramuscularly, delivers goserelin or a pharmaceutically acceptable salt thereof, for a period of at least one month.