METHODS FOR DIAGNOSING COLON CANCER AND STREPTOCOCCUS BOVIS PROTEINS FOR USE IN THE METHOD

摘要

The present invention relates to methods for diagnosing colon cancer in an individual, especially the diagnosis of an pre or early stage of colon cancer, comprising detecting the presence of immunoglobulin molecules directed against Streptococcus bovis antigens in a sample of the individual comprising total serum immunoglobulin molecules. The present invention further relates to antigens for use in said method and to the use of the antigens as a diagnosticum and/or medicament. Preferred antigens are HlpA and RpL7/L12. The most preferred detection method involves capturing the S. Bovis antigens on a solid support, to which the immunoglobulin analytes have been previously immobilized.