Growth factor mutants with altered biological attributes

摘要

The invention relates to novel recombinant growth factor mutants with altered biological attributes which are derived from proteins of the TGF-β superfamily of signalling molecules and exhibit novel antagonistic properties. They are particularly suitable for the determination of cell fates, the growth stimulation and differentiation of various cells including stem cells and the regeneration of organs. They are also useful for the supportive therapy of muscular diseases and treatment of disorders characterized by the excessive action of TGF-β superfamily members.