HUMAN MONOCLONAL ANTIBODY BINDING TO HUMAN GM-CSF AND ANTIGEN-BINDING SITE THEREOF

摘要

(PROBLEMS) It is intended to provide a human monoclonal antibody which has more enhanced affinity and neutralizing capacity against human GM-CSF whose overproduction becomes a cause of various disease conditions. (MEANS FOR SOLVING PROBLEMS) An anti-human GM-CSF monoclonal antibody which is a human monoclonal antibody binding to human GM-CSF and capable of neutralizing the biological activity thereof, characterized by having a light chain (L chain) represented by an amino acid sequence shown in SEQ ID NO: 1 and a heavy chain (H chain) represented by an amino acid sequence shown in SEQ ID NO: 2.