HUMAN MONOCLONAL ANTIBODY BINDING TO HUMAN GM-CSF AND ANTIGEN-BINDING SITE THEREOF

摘要

[PROBLEMS] The present invention aims to provide a human monoclonal antibody with higher affinity and neutralizing capacity to the hGM-CSF,whose overproduction causes various diseases. [MEANS FOR SOLVING PROBLEMS] An anti-hGM-CSF monoclonal antibody which is a human monoclonal antibody capable of binding to hGM-CSF and neutralizing bioactivity of the hGM-CSF, characterized in that the anti-hGM-CSF monoclonal antibody has a light chain (L chain) represented by an amino acid sequence of sequence number 1, and has a heavy chain (H chain) represented by an amino acid sequence of sequence number 2.