CHIMERIC MOUSE HAVING AN IMMUNE SYSTEM CONSTRUCTED WITH HUMAN CD34-POSITIVE CELLS AND USE THEREOF

摘要

Chimeric mice were constructed by transferring human CD34⁺ cells (hematopoietic stem cells) into a SCID mouse. In these chimeric mice, hematopoietic stem cells persistently differentiated into immune cells. Consequently, the chimeric mice can be immunized over a long time and enable one to obtain human antibodies against arbitrary antigens containing a human self-component.