METHODS AND COMPOSITIONS FOR USING ERYTHROCYTES AS CARRIERS FOR DELIVERY OF DRUGS

摘要

The present invention provides methods and compositions for using erythrocyte (RBC) as a carrier for delivery of drugs, e.g., therapeutic enzymes or mammalian serum proteins. The invention involves conjugating the drug to an antibody that binds RBC. When administered to a patient, the RBC binding conjugate binds to RBC, and is delivered to desired locations by the RBC. The invention provides methods of using the RBC binding conjugate for preventing and treating diseases. The invention also provides methods for preparing the RBC binding conjugate.