PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DISEASE ACCOMPANIED BY CHRONIC MUSCLE/SKELETON PAIN

摘要

A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A_2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R¹, R² and R³ are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R⁴ represents cycloalkyl, -(CH₂)_n-R⁵ or the following formula (II); and X¹ and X² are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.