PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DISEASE ACCOMPANIED BY CHRONIC MUSCLE/SKELETON PAIN

摘要

A prophylactic and/or therapeutic agent for diseases accompanied by chronic musculoskeletal pain comprising as an active ingredient a compound having an adenosine A 2A receptor antagonistic action, for example, represented by the following formula (I) (wherein R 1 , R 2 and R 3 are the same or different, each representing a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; R 4 represents cycloalkyl, -(CH 2 ) n -R 5 or the following formula (II); and X 1 and X 2 are the same or different, each representing an oxygen atom or a sulfur atom) or a pharmaceutically acceptable salt thereof.